Sophie

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       Amanda Seyfried as Sophie Hall, a fact checker living in New York. She goes on a pre-honeymoon with her fiance to Verona, Italy. While sightseeing, she finds "Juliet's House" with weeping women writing letters and leaving them there. She follows a young woman who takes the letters, and while helping her the next day, she finds a 50-year old letter and decided to write back, leading her to meet Claire, the woman who had written the letter. She embarks on a journey with Claire and her grandson Charlie to find Claire's long lost love. She is Charlie's love interest.

Charlie

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       Chris Egan as Charlie Wyman, Claire's unpleasant grandson (as he described himself). Although he appears to be like that, and also grumpy, Claire explains that he has a good heart, like his father. Charlie soon develops a relationship with Sophie, and he becomes her love interest.

Lorenzo & Claire

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       Vanessa Redgrave as Claire Smith-Wyman, the girl who wrote the letter to Juliet 50 years before. Sophie meets her after Charlie goes to Juliet's secretaries, and she follows him. She is a kind woman, and develops a close friendship with Sophie as they search for her Lorenzo, her long lost love whom she fell in love with when they were fifteen. Her parents did not approve of him, and they were separated. 
       Franco Nero as Lorenzo Bartolini, Claire's love interest and long lost love. He met her when they were fifteen years old, in Verona. Claire's parents did not approve of him, and soon they were separated. His son and grandson are both named Lorenzo Bartolini, and they work at a grape vineyard. Nero is Redgrave's real life husband. Roger Ebert, having interviewed both Nero and Redgrave on the set of Camelot, noted how the much of the love story between their characters is nearly autobiographical.

Victor

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        Gael Garcia Bernal as Victor, Sophie's chef fiance. He is constantly busy and barely has time with Sophie. Most of the time during their time in Verona, he is away in some other town while Sophie helps Claire and Charlie. He is even interested in Juliet's secretaries' kitchen's recipes.